People

Sanghee Nah, Ph.D.

KBSI, Principal Research Scientist
Principal Investigator of BDCC

Research Interests

neurodegenerative disease, cancer therapy, nonlinear optical microspectroscopy

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Nonlinear optical microspectroscopy is a promising technique for biomolecular imaging beyond fluorescence microscopy. The most fascinating aspect of it is how it uses pulsed lasers to simulates complex biosystems and visualize them with scattered colors at various energies off the samples, enabling the imaging of molecular, structural, and functional alterations at the subcellular level.
For instance, in multiphoton absorption-induced luminescence, near-infrared photons dive into the deep tissue and noninvasively locate the target molecules. Stimulated Raman scattering even amplifies extremely weak vibrational transition signals allowing for label-free extraction of molecular compositional changes in biosystems with outstanding sensitivity and specificity.
The current research uses nonlinear optical microspectroscopy to explore the immunological response and cell-to-cell interactions generated by ischemia and disease progression in the mouse brain. We aim to address the functions of glial cells as well as the mechanism of neurodegeneration in central nervous systems.

Recent Publications
  1. A novel chalcone derivative exerts anticancer effects by promoting apoptotic cell death of human pancreatic cancer cells, Bioorganic & Medicinal Chemistry (2023) 93, 117458
  2. Polarization‐driven ultrafast optical switching in TiS3 nanoribbons via anisotropic hot carrier dynamics, Advanced Optical Materials (2023), 2300370
  3. Transient sub-bandgap states in halide perovskite thin films, Nano letters (2018) 18 (2), 827-831
  4. Ultrafast imaging of carrier cooling in metal halide perovskite thin films, Nano letters (2018) 18 (2), 1044-1048
  5. Spatially segregated free-carrier and exciton populations in individual lead halide perovskite grains, Nature Photonics (2017) 11 (5), 285-288

Participating Faculty and Researchers

  • Myung Hee Nam, Ph.D.

    Principal Researcher

  • Joo-hee Chung, Ph.D.

    Senior Researcher

  • Hoi-bin Jeong, Ph.D.

    Senior Researcher

  • Mi Hyeon Cho, Ph.D.

    Senior Researcher

  • Min Soo Kang, Ph.D.

    Post-doctoral Researcher

Researchers
Joo-Yeong Jeon
Email : jjy0183@kbsi.re.kr
Research Interests : Bioimaging, Tissue imaging, Cell Live Imaging, Clearing and 3D biometric image analysis, Animal imaging, Neuroscience of the retina and brain
Myeong Ji Park
Email : audwl0213@kbsi.re.kr
Research Interests : Bioimaging research, Cancer biology